Feline autoimmune lymphoproliferative syndrome (ALPS) is an inherited disease which causes a reduced ability to trigger lymphocyte apoptosis. Lymphocyte consequently accumulate and expand lymph nodes and spleen. Kittens develop abnormal lymph nodes. Some kittens die in young age others are euthanized due to the development of anorexia and weight loss. Lymph nodes increase in size as the disease progresses, suggesting the abnormal lymph nodes are likely chronic.
Inheritance: autosomal recessive - read more
Mutation: FASLG gene
Genetic test: The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.
Disease control: read more
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.