Congenital Eye Malformations (CEM)

Eye Malformations can be caused by enviromental or genetic factors. A new form of CEM has been observed in Golden Retrievers with clinical signs including unilateral or bilateral retina dysplasia and/or optic nerve hyploplasia. In some severe cases dogs are euthanized due to bilateral changes, agressivity or some other severe clinical signs. A mutation in SIX6 gene has been observed in Golden Retrievers with CEM, suggesting a strong connection between the gene and the disease since this gene produces a transcription factor with a known role in eye development.

Inheritance: Autosomal dominant with incomplete penetrance

Mutation: SIX6 gene

Genetic test: The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.

Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.

Price:

48.80 €

  • You can order free sampling kit.
  • Only one sample is required for each animal, even if you order several tests.
  • Samples are stored for the option to order additional tests.
  • We offer expert assistance in interpreting the results.
Suitable for breeds
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