Gallbladder mucoceles is an inherited hepatobiliary disease in dogs. Affected dogs are exposed to unneutralized bile salts, resulting in greater mucin secretion, inflammation (cholecystitis) and possible rupture of the gallbladder. Inflammation (cholecystitis) can be very painful and can be fatal in some cases. Clinical signs are non-specific and include abdominal pain, vomiting, loss of appetite, jaundice, anorexia, fever, diarrhoea and bloating. There is currently no specific treatment available for this disease. The genetic test enables early detection of the disease in affected dogs, facilitating decisions regarding supportive treatment. If surgery is needed, you can do it sooner. Treatment with drugs or diet can prevent or at least delay the development of gallbladder mucocele.
Inheritance: autosomal dominant with incomplete penetrance
Mutation: ABCB4 gene
Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.
DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.