Congenital ichthyoses comprise a heterogeneous group of genodermatoses characterized by abnormal desquamation over the whole body. Different genodermatoses can occur in different dog breeds. In Golden Retrievers, dermatological signs include a mild, moderate or severe generalised scaling, initially with small to large whitish scales that progress to blackish scales. The ventral glabrous skin can be hyperpigmented and rough. Dermatological signs can be visible at as early as a few weeks of age.
Inheritance: autosomal recessive - read more
Mutation: PNPLA1 gene
Genetic test: The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.
Disease control: read more
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.