Junctional Epidermolysis Bullosa (JEB)

Junctional Epidermolysis Bullosa (JEB) is an inherited blistering disorder of the skin and mucous membranes. In Australian Shepherds the symptoms occur within the first weeks of life. Symptoms include widespread ulcers of the skin, footpads, and oral mucosa. Shedding of the claws can also be observed. Histopathological examinations demonstrate clefting of the epidermis from the underlying dermis within or just below the basement membrane. Because of the similar phenotypes with other EB diseases, JEB cannot be diagnosed with clinical sings alone, but additional methods need to be used. A mutation in LMAB3 gene was linked to JEB in Australian Shephard.

Inheritance: autosomal recessive - read more

Mutation: LAMB3 gene

Genetic test: The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.

Disease control: read more

Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.

Price:

48.80 €

  • You can order free sampling kit.
  • Only one sample is required for each animal, even if you order several tests.
  • Samples are stored for the option to order additional tests.
  • We offer expert assistance in interpreting the results.
Suitable for breeds
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