Muscular dystrophies are a group of inherited, degenerative disorders characterized by progressive muscular dysfunction. Clinical signs start at a few weeks of age, and lead to severe progressive muscle weakness that cause severe problems including problems with gait and standing. Genetic defect is located on chromosome x, therefore the disease is more often expressed in males as only one affected allele is needed for development of the disease. Females develop the disease only if they inherit two affected alleles. Affected puppies are usually euthanized.
Inheritance: X-linked recessive - read more
Mutation: DMD gene
Genetic test: The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.