Neonatal Cerebellar Cortical Degeneration (NCCD)is a hereditary disease which can be tested with a DNA test.Neonatal cerebellar cortical degeneration (NCCD) is a neurodegenerative hereditary disease found in several canine breeds including Beagles. NCCD in Beagle is characterised by clinical signs of cerebellar dysfunction, such as ataxia, crossing of legs, uncoordinated movement, loss of balance and tremor of the head and legs. First symptoms appear at around 3 weeks of age when puppies normally develop coordinated movement. The majority of puppies affected with NCCD are euthanized shortly after diagnosing the first signs of this disease.
Inheritance: autosomal recessive - read more
Mutation: SPTBN2 gene
Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.
Disease control: read more
DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.