Polycystic Kidney Disease (PKD) in Bull Terrier is an inherited autosomal dominant disease. The mutation in PKD1 gene causes dogs to develop kidney cysts filled with fluid. These cysts grow in size and number as the diseases progresses, gradually replacing healthy kidney tissue with non-functional cysts and thus impairing renal function. Chronic renal failure appears in middle to old age and leads to death. Although renal cysts can be detected by ultrasound screening, it is difficult to establish a definite diagnosis, especially early in the disease course.
Inheritance: autosomal dominant - read more
Mutation: PKD1 gene
Genetic test: The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.