Different forms of progressive retinal atrophies are documented in domestic cats. Progressive retinal atrophy in Bengal cats (b-PRA) is characterized by early onset of photoreceptor destruction in the retina. Ophthalmoscopic signs of retinal degeneration are observed at 9 weeks of age and become more noticeable over the next 4 months by which a complete and pan retinal degeneration is observed. Ophthalmic signs are always symmetrical. Affected cats older than 20 weeks have pupil diameter significantly greater than that of non-affected cats. Visual deficits are evident by 1 year of age.
Inheritance: autosomal recessive - read more
Mutation: KIF3B gene
Genetic test: The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.
Disease control: read more
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.