Renal cystadenocarcinoma and nodular dermatofibrosis (RCND)is a hereditary disease which can be tested with a DNA test. Canine hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis (RCND) is inherited genetic predisposition causing kidney, dermal and uterine cancer in German Shepherd Dogs. The syndrome is characterized by bilateral, multifocal tumours in kidneys and numerous firm nodules, consisting of dense collagen fibres in the skin and subcutis. In female dogs uterine cancer (benign smooth muscle tumour) is also present. Symptoms of the kidney cancer include blood in urine, polydipsia (excessive thirst or excess drinking), progressive weight loss, anorexia, vomiting, and respiratory distress.
Inheritance: autosomal dominant - read more
Mutation: FLCN gene
Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.
DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.