Progressive retinal atrophy (PRA) in dogs is a group of genetically heterogeneous inherited retinal disorders characterized by progressive degeneration and cell death of photoreceptors. X-linked progressive retinal atrophy (XL PRA) is an X-linked form of retinitis pigmentosa. Affected dogs have normal retina at birth. The first clinical symptoms appear at 6 months. Rod light receptors begin to appear irregularly damaged, later cone damage arises, and at an age of 4 years affected dogs are usually completely blind. Symptoms include progressive deterioration of central vision, mild photophobia, and moderate to high myopia.
Inheritance: X-linked recessive - read more
Mutation: RPGR gene
Genetic test: The method used for testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. Testing can be done at any age.
Sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.