Gangliosidosis GM1

Gangliosidosis GM1is a hereditary disease that can be tested with a DNA test. Gangliosidosis is an inherited error of lipid metabolism, also known as a 'lysosomal storage disease'. An autosomal recessively inherited deficiency of acid β-galactosidase activity affects brain and multiple systemic organs.GM1- gangliosidosis in Siberian Husky affects brain, causing progressive neurological impairment. Affected dogs suffer from paralysis of the extremities and spasticity of the muscles. At the age of about 8 months, most dogs die of this disease.

Portuguese Water Dogs affected with GM1- gangliosidosis develop nervous system manifestations including ataxia, seizures and changes in temperament. They rarely survive beyond 6 months of age.

Shiba Inu dogs affected with GM1- gangliosidosis develop nervous system manifestations including vision loss, walking difficulties, loss of balance, head tremors, lethargy and weight loss. First symptoms appear around 5 to 6 months of age, by 9 to 12 months of age affected dogs are lethargic, have cloudy corneas, and may have involuntary muscle contractions. Dogs usually die by 15 months of age. 

 

Inheritance: autosomal recessive - read more

Mutation: GLB1 gene

Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.

Disease control: read more

DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.

Price:

52.00 €

  • You can order free sampling kit.
  • Only one sample is required for each animal, even if you order several tests.
  • Samples are stored for the option to order additional tests.
  • We offer expert assistance in interpreting the results.
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