Hyperuricosuria (HUU) is a hereditary disease that can be tested with a DNA test for dogs. Hyperuricosuria is a hereditary disease characterised by excessive excretion of uric acid into the urine, leading to formation of uric acid stones. this hereditary disease is caused by mutation G563T in SLC2A9 gene that codes for uric acid transport protein expressed in kidneys. The mutation was first discoverd in Dalmatian dogs. However in wider population screen it was also found frequently in Bulldog, Black Russian Terrier, American Staffordshire Terrier as well as retrievers. Mutation is present in many other breeds
Inheritance: autosomal recessive - read more
Mutation: SLC2A9 gene
Genetic test: The method used for genetic testing is extremely accurate and allows complete differentiation between affected animals, carriers and healthy dogs. DNA testing can be done at any age.
Disease control: read more
DNA test sample: EDTA whole blood (1.0 ml) or buccal swabs. Detailed information about sampling can be found here.